7 days in Mississippi & Florida Itinerary

A busy city on the Gulf Coast, Biloxi is one of the nation's oldest communities, first settled by Europeans in 1699.

To see photos, more things to do, ratings, and other tourist information, read our Biloxi vacation app .

New York City to Biloxi is an approximately 7-hour combination of bus and flight. You can also do a combination of bus, flight, and car; or drive. The time zone difference when traveling from New York City to Biloxi is minus 1 hour. Traveling from New York City in December, expect Biloxi to be somewhat warmer, temps between 64°F and 49°F. Finish your sightseeing early on the 10th (Tue) so you can travel to Orlando.

For most people, any mention of Orlando immediately conjures up images of sprawling theme parks filled with characters plucked right out of popular animated movies.

Orlando is known for theme parks, nightlife, fun & games, shopping, and museums. Your plan includes some of its best attractions: get in on the family fun at Walt Disney World Resort, admire the masterpieces at Charles Hosmer Morse Museum of American Art, get your game on at Nomadic, and make an unforgettable trip to Happily Ever After Fireworks.

To find ratings, traveler tips, other places to visit, and tourist information, you can read our Orlando journey builder app .

You can fly from Biloxi to Orlando in 4.5 hours. Other options are to do a combination of car and flight; or drive. The time zone difference moving from Central Standard Time (CST) to Eastern Standard Time (EST) is 1 hour. Expect a bit warmer temperatures when traveling from Biloxi in December; daily highs in Orlando reach 77°F and lows reach 59°F. Finish up your sightseeing early on the 13th (Fri) so you can travel to Key West.

Located just 140 km (90 mi) from Cuba, Key West is an island only about 6.4 km (4 mi) long and 1.6 km (1 mi) wide.

Kick off your visit on the 14th (Sat): take in the waterfront at Mallory Square, then see the interesting displays at The Ernest Hemingway Home and Museum, then look for all kinds of wild species at Key West Butterfly & Nature Conservatory, and finally explore the different monuments and memorials at Key West Cemetery. On your second day here, take a memorable tour with Tours, then explore the galleries of Truman Little White House, and then glide through the air with a parasailing or paragliding tour.

For where to stay, maps, other places to visit, and more tourist information, refer to the Key West trip itinerary builder website .

Fly from Orlando to Key West in 4.5 hours. Alternatively, you can drive; or take a bus. Plan for somewhat warmer nights when traveling from Orlando in December since evenings lows in Key West dip to 71°F. Finish up your sightseeing early on the 15th (Sun) so you can travel back home.