7 days in Mississippi & Florida Itinerary

A busy city on the Gulf Coast, Biloxi is one of the nation's oldest communities, first settled by Europeans in 1699.

To see reviews, traveler tips, photos, and other tourist information, go to the Biloxi journey planner.

New York City to Biloxi is an approximately 7.5-hour flight. You can also drive; or take a bus. The time zone difference when traveling from New York City to Biloxi is minus 1 hour. In December, Biloxi is somewhat warmer than New York City - with highs of 64°F and lows of 49°F. Finish up your sightseeing early on the 10th (Tue) so you can travel to Orlando.

For most people, any mention of Orlando immediately conjures up images of sprawling theme parks filled with characters plucked right out of popular animated movies.

Orlando is known for theme parks, nightlife, and fun & games. Your plan includes some of its best attractions: get in on the family fun at Walt Disney World Resort, make an unforgettable trip to Happily Ever After Fireworks, test your problem-solving skills at The Escape Game Orlando, and get your game on at Nomadic.

For more things to do, maps, photos, and more tourist information, you can read our Orlando route builder.

Getting from Biloxi to Orlando by flight takes about 5 hours. Other options: drive; or take a bus. The time zone difference when traveling from Biloxi to Orlando is 1 hour. Traveling from Biloxi in December, expect Orlando to be a bit warmer, temps between 77°F and 59°F. Finish your sightseeing early on the 13th (Fri) to allow enough time to travel to Key West.

Located just 140 km (90 mi) from Cuba, Key West is an island only about 6.4 km (4 mi) long and 1.6 km (1 mi) wide.

Kick off your visit on the 14th (Sat): take a leisurely stroll along Mallory Square, then see the interesting displays at The Ernest Hemingway Home and Museum, then look for all kinds of wild species at Key West Butterfly & Nature Conservatory, and finally explore the different monuments and memorials at Key West Cemetery. Get ready for a full day of sightseeing on the 15th (Sun): discover the deep blue sea with a scuba or snorkeling tour, contemplate the long history of Truman Little White House, and then glide through the air with a parasailing or paragliding tour.

For ratings, photos, reviews, and other tourist information, read Key West day trip planning tool.

Getting from Orlando to Key West by flight takes about 4.5 hours. Other options: drive; or take a bus. Expect a bit warmer evenings in Key West when traveling from Orlando in December, with lows around 71°F. Wrap up your sightseeing on the 15th (Sun) to allow time to travel back home.