41 days in Argentina, Chile & Bolivia Itinerary

41 days in Argentina, Chile & Bolivia Itinerary

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Route & dates

Start: San Francisco, United States
Fly:  18 h 15 min
1
La Paz, Bolivia
— 3 nights
Drive:  3 h
2
Copacabana, Bolivia
— 2 nights
Fly:  5 h 45 min
3
Uyuni, Bolivia
— 2 nights
Drive:  4 h 15 min
4
Tupiza, Bolivia
— 1 night
Drive:  3 h 45 min
5
Potosi, Bolivia
— 2 nights
Drive:  3 h
6
Sucre, Bolivia
— 3 nights
Fly:  2 h 15 min
7
Santa Cruz, Bolivia
— 4 nights
Fly:  2 h 30 min
8
Salta, Argentina
— 1 night
Fly:  2 h 15 min
9
Iguazu National Park, Argentina
— 2 nights
Fly:  3 h 30 min
10
Buenos Aires, Argentina
— 2 nights
Fly:  5 h 15 min
11
San Carlos de Bariloche, Argentina
— 2 nights
Fly:  3 h 30 min
12
Mendoza, Argentina
— 2 nights
Drive:  5 h
13
San Agustin del Valle Fertil, Argentina
— 3 nights
Drive:  13 h 30 min
14
San Pedro de Atacama, Chile
— 2 nights
Fly:  5 h
15
Santiago, Chile
— 2 nights
Fly:  6 h 30 min
16
Ancud, Chile
— 2 nights
Fly:  10 h 15 min
17
Hanga Roa, Chile
— 3 nights
Fly:  21 h 30 min
End: San Francisco, United States

3
nights
La Paz, Bolivia

Take a moment to catch your breath as you commence your holiday in La Paz.
Step out of the city life by going to Adrenaline & Extreme Tours and Valley of the Moon. Tiwanaku and Iglesia de San Francisco are good opportunities to explore the local culture. Change things up with a short trip to Puma Punku in Tiahuanaco (about 1h 10 min away). Spend the 4th (Sun) exploring the striking scenery along WMDR Yungas Road. There's more to do: make a trip to Mercado de Las Brujas and look for gifts at Unique.

For more things to do, photos, and tourist information, read our La Paz tour app.

San Francisco, USA to La Paz is an approximately 18.5-hour flight. Due to the time zone difference, you'll lose 4 hours traveling from San Francisco to La Paz. Traveling from San Francisco in October, expect nights in La Paz to be cooler, around 34°F, while days are a bit cooler, around 61°F. Wrap up your sightseeing on the 5th (Mon) early enough to drive to Copacabana.

Things to do in La Paz

Outdoors Historic Sites Scenic Drive

Side Trip

Puma Punku
Find places to stay Oct 2 — 5:
Highlights from your plan
Adrenaline & Extreme Tours
Tiwanaku ©
Tiwanaku
Puma Punku ©
Puma Punku

2
nights
Copacabana, Bolivia

Copacabana ©
The town of Copacabana represents the largest Bolivian settlement on the shore of Lake Titicaca, the largest lake in the continent.
Start off your visit on the 6th (Tue): contemplate in the serene atmosphere at Cerro Calvario and then admire all the interesting features of Isla del Sol. On the 7th (Wed), you'll have a packed day of sightseeing: take in the spiritual surroundings of Basilica of Our Lady of Copacabana and then contemplate the waterfront views at Lake Titicaca.

For photos, reviews, maps, and tourist information, use the Copacabana trip planner.

Traveling by car from La Paz to Copacabana takes 3.5 hours. Alternatively, you can take a bus. Wrap up your sightseeing on the 7th (Wed) early enough to travel to Uyuni.

Things to do in Copacabana

Historic Sites Nature Parks
Find places to stay Oct 5 — 7:
Highlights from your plan
Isla del Sol ©
Isla del Sol
Cerro Calvario ©
Cerro Calvario
Basilica of Our Lady of Copacabana
Basilica of Our Lady of Copacabana

2
nights
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
Start off your visit on the 8th (Thu): step off the mainland to explore Isla Incahuasi and then explore the striking landscape at Salar de Uyuni. Get ready for a full day of sightseeing on the next day: see the interesting displays at Museo de la Llama y la Sal, don't miss a visit to Plaza Arce, thensee the interesting displays at Train Cemetery, and finally learn more about the world around you at Museo Arquecologia y Antropologico de los Andes Meridionales.

To see traveler tips, reviews, other places to visit, and more tourist information, read our Uyuni itinerary planning site.

You can fly from Copacabana to Uyuni in 7.5 hours. Alternatively, you can drive; or do a combination of bus and taxi. In October in Uyuni, expect temperatures between 45°F during the day and 44°F at night. Finish your sightseeing early on the 9th (Fri) to allow enough time to drive to Tupiza.

Things to do in Uyuni

Nature Parks Museums

Side Trip

Museo de la Llama y la Sal
Find places to stay Oct 7 — 9:
Highlights from your plan
Salar de Uyuni ©
Salar de Uyuni
Isla Incahuasi ©
Isla Incahuasi
Train Cemetery ©
Train Cemetery

1
night
Tupiza, Bolivia

The southwestern mining town of Tupiza, near the Argentine border, reminisces of the wild west, and is supposedly the place where Butch Cassidy and the Sundance Kid faced their demise after a long string of bank robberies.
Kick off your visit on the 10th (Sat): see Off-Road Tours.

To find photos, reviews, maps, and more tourist information, go to the Tupiza trip planning app.

Drive from Uyuni to Tupiza in 4.5 hours. Alternatively, you can do a combination of taxi and train; or do a combination of taxi and bus. Wrap up your sightseeing on the 10th (Sat) early enough to drive to Potosi.

Things to do in Tupiza

Outdoors Tours
Find places to stay Oct 9 — 10:
Highlights from your plan
Off-Road Tours

2
nights
Potosi, Bolivia

Potosi ©
One of the highest cities in the world at 4,090 m (13,420 ft), Potosi actually rose to fame for something below the ground.
Start off your visit on the 11th (Sun): witness a stunning natural landmark at Ojo del Inca and then see the interesting displays at Casa Nacional de la Moneda. Get ready for a full day of sightseeing on the next day: get outside with Gruta De Las Galaxias, thenmingle with the ghosts of the past at Pueblo Pulacayo, and then contemplate the long history of Cerro Rico.

For traveler tips, maps, ratings, and other tourist information, read Potosi trip planner.

You can drive from Tupiza to Potosi in 4 hours. Another option is to take a bus. Expect a daytime high around 62°F in October, and nighttime lows around 33°F. Wrap up your sightseeing on the 12th (Mon) to allow time to drive to Sucre.

Things to do in Potosi

Historic Sites Nature Parks
Find places to stay Oct 10 — 12:
Highlights from your plan
Cerro Rico ©
Cerro Rico
Pueblo Pulacayo ©
Pueblo Pulacayo
Casa Nacional de la Moneda ©
Casa Nacional de la Moneda

3
nights
Sucre, Bolivia

Sucre ©
The constitutional capital of Bolivia, Sucre has a well-preserved historic center, with many buildings dating back to the city's founding in the 16th century.
Take a break from the city and head to Icla Canyon and Climbing Tours. Get some historical perspective at Museum of the Cathedral - Museo de la Catedral and La Recoleta. The adventure continues: admire the masterpieces at Museum of Indigenous Art ASUR, take in the exciting artwork at Arte y Cultura Sucre Galeria, get outside with La Maja, and get curious at Museo del Tesoro.

To see other places to visit, ratings, more things to do, and more tourist information, go to the Sucre travel route planner.

Getting from Potosi to Sucre by car takes about 3 hours. Other options: take a bus; or take a train. Traveling from Potosi in October, things will get somewhat warmer in Sucre: highs are around 72°F and lows about 48°F. Finish up your sightseeing early on the 15th (Thu) so you can travel to Santa Cruz.

Things to do in Sucre

Museums Historic Sites Outdoors
Find places to stay Oct 12 — 15:
Highlights from your plan
House of Liberty Museum - Casa de la Libertad ©
Museum of Indigenous Art ASUR ©
Museum of Indigenous Art ASUR

4
nights
Santa Cruz, Bolivia

Santa Cruz ©
More populous than the capital and La Paz, and one of the fastest-growing cities in the world, Santa Cruz has become a thriving commercial center, yet retained some of the trappings of tradition.
Satisfy your inner culture vulture at Catedral de Santa Cruz and Museo Artecampo. Take a break from the city and head to Noel Kempff Mercado National Park and Amboro National Park. There's still lots to do: take in nature's colorful creations at Guembe, make a trip to Plaza 24 de Septiembre, get into the urban bustle at Casa Cultural Melchor Pinto, and take in the architecture and atmosphere at Parroquia de la Inmaculada Concepcion.

To find photos, reviews, other places to visit, and more tourist information, go to the Santa Cruz trip itinerary maker app.

Fly from Sucre to Santa Cruz in 2.5 hours. Alternatively, you can drive; or take a bus. Expect a bit warmer weather when traveling from Sucre in October: highs in Santa Cruz hover around 89°F, while lows dip to 70°F. Finish up your sightseeing early on the 19th (Mon) so you can travel to Salta.

Things to do in Santa Cruz

Parks Nature Historic Sites

Side Trip

Amboro National Park
Find places to stay Oct 15 — 19:
Highlights from your plan
Noel Kempff Mercado National Park ©
Noel Kempff Mercado National Park
Catedral de Santa Cruz ©
Catedral de Santa Cruz
Parroquia de la Inmaculada Concepcion ©
Parroquia de la Inmaculada Concepcion

1
night
Salta, Argentina

Salta ©
Salta boasts a vibrant social life and array of informative museums appealing to visitors looking for a memorable cultural experience.
Kick off your visit on the 19th (Mon): contemplate in the serene atmosphere at Virgen de los Tres Cerritos, pause for some photo ops at Monumento General Martín Miguel de Güemes, take your sightseeing to a higher altitude at Cerro San Bernardo, don't miss a visit to Plaza Anfiteatro, thencontemplate in the serene atmosphere at Cathedral of Salta, and finally examine the collection at Salta Cabildo. Get ready for a full day of sightseeing on the next day: don't miss a visit to Plazoleta IV Siglos, learn more about the world around you at MAAM - Museo de Arqueologia de Alta Montana de Salta, make a trip to Plaza 9 de Julio, stop by Almandina, thencontemplate in the serene atmosphere at Basilica Menor San Francisco, and finally take in the architecture and atmosphere at Iglesia Nuestra Senora de La Candelaria de La Vina.

To see more things to do, photos, other places to visit, and other tourist information, you can read our Salta trip itinerary app.

Fly from Santa Cruz to Salta in 5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll lose 1 hour traveling from Santa Cruz to Salta. Prepare for a bit cooler weather when traveling from Santa Cruz in October: high temperatures in Salta hover around 79°F and lows are around 53°F. Wrap up your sightseeing on the 20th (Tue) to allow time to travel to Iguazu National Park.

Things to do in Salta

Historic Sites Museums Nature
Find places to stay Oct 19 — 20:
Highlights from your plan
Basilica Menor San Francisco ©
Basilica Menor San Francisco
Cathedral of Salta ©
Cathedral of Salta
Virgen de los Tres Cerritos ©
Virgen de los Tres Cerritos

2
nights
Iguazu National Park, Argentina

Iguazu National Park ©
Iguazu National Park contains 672 sq km (259 sq mi) of fertile subtropical forests, but its main attraction is the majestic Iguazu Falls.
On the 21st (Wed), take in the dramatic scenery at Salto Bernabe Mendez and then take in the dramatic scenery at Iguazu Falls. On the 22nd (Thu), you'll have a packed day of sightseeing: discover the riches below the earth's surface at Wanda Mines, contemplate the waterfront views at Lago Urugua-i, thentake in the dramatic scenery at Salto San Martin, and finally step off the mainland to explore Isla San Martin.

To see where to stay, traveler tips, other places to visit, and tourist information, use the Iguazu National Park trip website.

Traveling by flight from Salta to Iguazu National Park takes 4 hours. Alternatively, you can drive; or take a bus. Traveling from Salta in October, expect a bit warmer with lows of 62°F in Iguazu National Park. Finish your sightseeing early on the 22nd (Thu) to allow enough time to travel to Buenos Aires.

Things to do in Iguazu National Park

Nature Parks Wildlife

Side Trips

Lago Urugua-i, Wanda Mines
Find places to stay Oct 20 — 22:
Highlights from your plan
Iguazu Falls ©
Iguazu Falls
Salto Bernabe Mendez ©
Salto Bernabe Mendez
Salto San Martin ©
Salto San Martin

2
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Kick off your visit on the 23rd (Fri): take in nature's colorful creations at Jardin Japones, admire the natural beauty at Parque 3 de Febrero, admire the masterpieces at Museo Nacional de Bellas Artes, thenexplore the different monuments and memorials at Cemiterio de Recoleta, and finally stop by El Ateneo Grand Splendid. Here are some ideas for day two: ponder the world of politics at Casa Rosada, thenadmire the architecture and history at Plaza de Mayo, thenget a taste of the local shopping with Puerto Madero, and finally get to know the fascinating history of Calle Defensa.

To find other places to visit, photos, and more tourist information, go to the Buenos Aires road trip site.

Fly from Iguazu National Park to Buenos Aires in 4 hours. Alternatively, you can drive; or take a bus. Traveling from Iguazu National Park in October, you will find days in Buenos Aires are little chillier (69°F), and nights are about the same (58°F). Finish your sightseeing early on the 24th (Sat) to allow enough time to travel to San Carlos de Bariloche.

Things to do in Buenos Aires

Historic Sites Neighborhoods Parks
Find places to stay Oct 22 — 24:
Highlights from your plan
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Parque 3 de Febrero ©
Parque 3 de Febrero
Calle Defensa ©
Calle Defensa

2
nights
San Carlos de Bariloche, Argentina

San Carlos de Bariloche
Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Kick off your visit on the 25th (Sun): identify plant and animal life at Wildlife Areas and then tour the pleasant surroundings at Catedral Alta Patagonis. Get ready for a full day of sightseeing on the next day: get great views at Cerro Otto, thentrek along Circuito Chico, and then take in the spiritual surroundings of Parroquia San Eduardo.

To see other places to visit, maps, more things to do, and other tourist information, read our San Carlos de Bariloche trip itinerary site.

Traveling by flight from Buenos Aires to San Carlos de Bariloche takes 5.5 hours. Alternatively, you can drive; or take a bus. When traveling from Buenos Aires in October, plan for slightly colder days and colder nights in San Carlos de Bariloche: temperatures range from 58°F by day to 34°F at night. Finish up your sightseeing early on the 26th (Mon) so you can travel to Mendoza.

Things to do in San Carlos de Bariloche

Parks Outdoors Winter Sports
Find places to stay Oct 24 — 26:
Highlights from your plan
Catedral Alta Patagonis
Catedral Alta Patagonis
Circuito Chico ©
Circuito Chico
Cerro Otto ©
Cerro Otto

2
nights
Mendoza, Argentina

Mendoza ©
Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Start off your visit on the 27th (Tue): do a tasting at Bodega Roberto Bonfanti, thenlearn about winemaking at Bodega Ruca Malen, thendo a tasting at Bodega La Azul, and finally admire the striking features of Colegio Nacional Agustin Alvarez. On the 28th (Wed), you'll have a packed day of sightseeing: take in the architecture and atmosphere at Santuario de Maria Auxiliadora, take in the architecture and atmosphere at Nuestra Senora del Perpetuo Socorro, learn about winemaking at Bodega Tierras Altas, appreciate the extensive heritage of Plaza Espana, thentake in the architecture and atmosphere at Santuario Virgen de Lourdes, and finally stroll around Parque General San Martin.

To see other places to visit, where to stay, more things to do, and other tourist information, use the Mendoza road trip tool.

You can fly from San Carlos de Bariloche to Mendoza in 4 hours. Other options are to drive; or take a bus. Traveling from San Carlos de Bariloche in October, things will get somewhat warmer in Mendoza: highs are around 76°F and lows about 53°F. Cap off your sightseeing on the 28th (Wed) early enough to travel to San Agustin del Valle Fertil.

Things to do in Mendoza

Wineries Historic Sites Parks

Side Trips

Santuario Virgen de Lourdes, Santuario de Maria Auxiliadora
Find places to stay Oct 26 — 28:
Highlights from your plan
Bodega Tierras Altas ©
Bodega Tierras Altas
Bodega Roberto Bonfanti ©
Bodega Roberto Bonfanti
Bodega Ruca Malen ©
Bodega Ruca Malen

3
nights
San Agustin del Valle Fertil, Argentina

San Agustin del Valle Fertil ©
On the 29th (Thu), explore the galleries of Provincial Ischigualasto Park and then examine the collection at Museo Piedras del Mundo.

To find traveler tips, where to stay, reviews, and other tourist information, read San Agustin del Valle Fertil trip builder website.

Traveling by car from Mendoza to San Agustin del Valle Fertil takes 5 hours. On the 31st (Sat), you'll travel to San Pedro de Atacama.

Things to do in San Agustin del Valle Fertil

Museums Nature Parks
Find places to stay Oct 28 — 31:
Highlights from your plan
Provincial Ischigualasto Park ©
Provincial Ischigualasto Park
Museo Piedras del Mundo ©
Museo Piedras del Mundo

2
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
Kick off your visit on the 1st (Sun): explore the ancient world of Pukara de Quitor, engage your brain at Museo del Meteorito, thenwitness a stunning natural landmark at Geyser del Tatio, and finally see the interesting displays at Father Le Paige Museum. Get ready for a full day of sightseeing on the 2nd (Mon): look and learn at Observatorio Etno-Astronomico Licanantay, take in the dramatic natural features at Valle De La Luna, and then admire the landmark architecture of Iglesia de San Pedro de Atacama.

To find where to stay, other places to visit, maps, and tourist information, refer to the San Pedro de Atacama trip planner.

Traveling by car from San Agustin del Valle Fertil to San Pedro de Atacama takes 17.5 hours. Alternatively, you can do a combination of car and flight. The time zone difference moving from Argentina Standard Time (ART) to Chile Standard Time (CLT) is minus 1 hour. In October, plan for daily highs up to 76°F, and evening lows to 38°F. Wrap up your sightseeing on the 2nd (Mon) to allow time to travel to Santiago.

Things to do in San Pedro de Atacama

Museums Nature Parks
Find places to stay Oct 31 — Nov 2:
Highlights from your plan
Observatorio Etno-Astronomico Licanantay ©
Observatorio Etno-Astronomico Licanantay
Valle De La Luna ©
Valle De La Luna
Geyser del Tatio ©
Geyser del Tatio

2
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Kick off your visit on the 3rd (Tue): steep yourself in history at Centro Cultural Palacio de la Moneda y Plaza de la Ciudadania, thentake in the spiritual surroundings of Iglesia de La Merced, thenexamine the collection at La Chascona, and finally pause for some serene contemplation at Iglesia de Santa Filomena. On the 4th (Wed), you'll have a packed day of sightseeing: take in the spiritual surroundings of Monasterio Agustinas de la Limpia Concepcion, thentake in the awesome beauty at San Cristóbal Hill, and then wander the streets of Barrio Bellavista.

To find ratings, traveler tips, where to stay, and tourist information, go to the Santiago trip itinerary planner.

Getting from San Pedro de Atacama to Santiago by flight takes about 5.5 hours. Other options: drive; or take a bus. Finish your sightseeing early on the 4th (Wed) to allow enough time to travel to Ancud.

Things to do in Santiago

Historic Sites Nature Parks
Find places to stay Nov 2 — 4:
Highlights from your plan
San Cristóbal Hill ©
San Cristóbal Hill
La Chascona ©
La Chascona

2
nights
Ancud, Chile

Ancud ©
A city of 40,000 people, Ancud was the capital of Chiloe Archipelago until it was superseded by the city of Castro in 1982.
Start off your visit on the 5th (Thu): take an in-depth tour of Museo de Las Iglesias de Chiloe, examine the collection at Museo Regional de Ancud, thenmake a trip to Fuerte San Antonio, and finally expand your understanding of the military at Fuerte Ahui. Get ready for a full day of sightseeing on the next day: enjoy the sea views from Faro Corona en Chiloe and then see the interesting displays at Museo Bomberil Cuerpo de Bomberos de Ancud.

To see more things to do, where to stay, traveler tips, and tourist information, read our Ancud online trip itinerary planner.

Traveling by flight from Santiago to Ancud takes 7 hours. Alternatively, you can take a bus. Expect a daytime high around 59°F in November, and nighttime lows around 43°F. Wrap up your sightseeing by early afternoon on the 6th (Fri) to allow time for travel to Hanga Roa.

Things to do in Ancud

Historic Sites Museums
Find places to stay Nov 4 — 6:
Highlights from your plan
Faro Corona en Chiloe ©
Faro Corona en Chiloe
Museo Regional de Ancud ©
Museo Regional de Ancud
Museo de Las Iglesias de Chiloe ©
Museo de Las Iglesias de Chiloe

3
nights
Hanga Roa, Chile

Hanga Roa ©
The main town and capital of Chile's Easter Island, Hanga Roa serves as a base for most visitors to the island, with all explorations of Easter Island and its famous moai monoliths beginning here.
Kick off your visit on the 7th (Sat): stroll the grounds of Cementerio de Isla de Pascua, enjoy the sand and surf at Playa Pea, steep yourself in history at Ahu Tahai, thendelve into the distant past at Ahu Nau Nau, and finally enjoy the sand and surf at Anakena. Keep things going the next day: look for gifts at Tamure Shop, explore the striking landscape at Orongo, contemplate the geological forces at Rano Kau, delve into the distant past at One Makihi, thenmake a trip to Hanga Te Tenga, and finally make a trip to Ahu Hanga Te'e.

To find other places to visit, ratings, traveler tips, and other tourist information, read Hanga Roa online sightseeing planner.

Fly from Ancud to Hanga Roa in 12 hours. The time zone difference when traveling from Ancud to Hanga Roa is minus 2 hours. When traveling from Ancud in November, plan for somewhat warmer days and much hotter nights in Hanga Roa: temperatures range from 73°F by day to 64°F at night. Wrap up your sightseeing by early afternoon on the 9th (Mon) to allow time for travel back home.

Things to do in Hanga Roa

Parks Historic Sites Nature

Side Trip

Easter Island
Find places to stay Nov 6 — 9:
Highlights from your plan
Rano Raraku ©
Rano Raraku
Anakena ©
Anakena
Orongo ©
Orongo

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