21 days in Spain, France & Italy Itinerary

21 days in Spain, France & Italy Itinerary

Created using Inspirock Europe tour itinerary planner

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Route & dates

Start: Boston, United States
Fly:  10 h
1
Madrid, Spain
— 2 nights
Train:  3 h
2
Barcelona, Spain
— 4 nights
train:  5 h 30 min
3
Paris, France
— 2 nights
train:  5 h
4
Venice, Italy
— 4 nights
Bus:  4 h 30 min
5
Florence, Italy
— 3 nights
bus:  2 h
6
Rome, Italy
— 3 nights
Fly:  12 h 30 min
End: Boston, United States

2
nights
Madrid, Spain

Madrid ©
Madrid is known for its cultural and artistic heritage, lively nightlife, and a dynamic culinary scene.
Museum-lovers will get to explore Prado National Museum and Alcazar of Segovia. You'll discover tucked-away gems like Catedral de Segovia and Museo Sorolla. Change things up with these side-trips from Madrid: The Walls of Avila (in Avila) and Monastery of San Juan de los Reyes (in Toledo). The adventure continues: steep yourself in history at Royal Palace of Madrid and examine the collection at Museo Nacional Thyssen-Bornemisza.

For where to stay, maps, traveler tips, and more tourist information, read Madrid road trip planner.

Boston, USA to Madrid is an approximately 10- hour flight. The time zone changes from Eastern Standard Time to Central European Standard Time, which is usually a 6 hour difference. Traveling from Boston in October, expect nights in Madrid to be about the same, around 53°F, while days are somewhat warmer, around 73°F. On the 21st (Mon), wrap the sightseeing up by early afternoon so you can take a train to Barcelona.

Things to do in Madrid

Museums Historic Sites

Side Trips

Segovia, The Walls of Avila, Monastery of San Juan de los Reyes
Find places to stay Oct 19 — 21:
Highlights from your plan
Prado National Museum ©
Prado National Museum
Alcazar of Segovia ©
Alcazar of Segovia
Catedral de Segovia ©
Catedral de Segovia

4
nights
Barcelona, Spain

Barcelona ©
Barcelona, the country’s second-largest city, is a cosmopolitan urban center known for its throbbing youthful energy and stellar architecture.
Your inner history buff will appreciate Basilica of the Sagrada Familia and Girona Cathedral (Catedral). Carrer del Mirador del Palau Nacional and Museu d'Història de Barcelona MUHBA will appeal to museum buffs. Change things up with a short trip to Patronat Call de Girona in Girona (about 1h 20 min away). The adventure continues: visit El Barri Gòtic, admire the landmark architecture of Casa Mila - La Pedrera, explore the world behind art at Museu Picasso, and make a trip to Casa Batllo.

To find ratings, more things to do, photos, and more tourist information, read our Barcelona itinerary planner.

Take a train from Madrid to Barcelona in 3 hours. Alternatively, you can fly; or drive. Traveling from Madrid in October, expect a bit warmer with lows of 60°F in Barcelona. Wrap up your sightseeing on the 25th (Fri) to allow time to travel to Paris.

Things to do in Barcelona

Museums Historic Sites Neighborhoods

Side Trip

Girona
Find places to stay Oct 21 — 25:
Highlights from your plan
Basilica of the Sagrada Familia ©
Basilica of the Sagrada Familia
El Barri Gòtic ©
El Barri Gòtic
Girona Cathedral (Catedral) ©
Girona Cathedral (Catedral)

2
nights
Paris, France

Paris ©
A beautiful and romantic city fit for any itinerary, Paris brims with historic associations and remains vastly influential in the realms of culture, art, fashion, food and design.
Eiffel Tower and Palace of Versailles are good opportunities to explore the local culture. Get some historical perspective at Basilique du Sacre-Coeur de Montmartre and Île de la Cité. There's lots more to do: admire the masterpieces at Louvre Museum, take a stroll through Montmartre, and admire the striking features of Arc de Triomphe.

To find photos, ratings, more things to do, and other tourist information, read our Paris trip planner.

Traveling by flight from Barcelona to Paris takes 5 hours. Alternatively, you can do a combination of train, bus, and flight; or drive. In October, Paris is slightly colder than Barcelona - with highs of 62°F and lows of 48°F. Finish up your sightseeing early on the 27th (Sun) so you can travel to Venice.

Things to do in Paris

Historic Sites Museums Neighborhoods

Side Trip

Palace of Versailles
Find places to stay Oct 25 — 27:
Highlights from your plan
Louvre Museum ©
Louvre Museum
Eiffel Tower ©
Eiffel Tower
Musee d'Orsay ©
Musee d'Orsay

4
nights
Venice, Italy

Venice ©
Virtually unchanged for the last six centuries, Venice is actually a group of islands made famous by a series of canals, bridges, monuments, piazzas, and narrow pedestrian lanes.
Satisfy your inner culture vulture at Doge's Palace and Peggy Guggenheim Collection. Step off the beaten path and head to San Giorgio Maggiore and Basilica di Santa Giustina. Explore Venice's surroundings by going to Padua (Orto Botanico di Padova & Piazza dei Signori) and Verona (San Fermo Maggiore, Verona, Piazzale Castel San Pietro, &more). The adventure continues: admire the striking features of Basilica di San Marco, steep yourself in history at Venetian Arsenal, contemplate in the serene atmosphere at Church of San Pantalon, and pause for some serene contemplation at Basilica di Santa Maria della Salute.

Plan a Venice trip in moments using our itinerary builder.

Getting from Paris to Venice by flight takes about 5 hours. Other options: do a combination of train, shuttle, and flight; or drive. Expect a daytime high around 66°F in October, and nighttime lows around 51°F. Cap off your sightseeing on the 31st (Thu) early enough to catch the train to Florence.

Things to do in Venice

Historic Sites Museums Parks

Side Trips

Verona, Padua
Find places to stay Oct 27 — 31:
Highlights from your plan
Doge's Palace ©
Doge's Palace
Piazza San Marco ©
Piazza San Marco
Peggy Guggenheim Collection ©
Peggy Guggenheim Collection

3
nights
Florence, Italy

Florence ©
Considered a cultural, artistic, and architectural jewel of Italy, Florence is the birthplace of the Italian Renaissance.
You'll discover tucked-away gems like Piazza del Duomo and Ponte Vecchio. Deepen your sense of the past at sights like Duomo di Pisa and Centro Storico. The adventure continues: admire the masterpieces at Gallerie Degli Uffizi, see the interesting displays at Pitti Palace, don't miss a visit to Piazzale Michelangelo, and appreciate the history behind Loggia dei Lanzi.

For ratings, photos, other places to visit, and more tourist information, read our Florence online trip itinerary planner.

You can take a train from Venice to Florence in 2.5 hours. Other options are to drive; or take a bus. Expect a daytime high around 71°F in October, and nighttime lows around 54°F. Finish your sightseeing early on the 3rd (Sun) so you can take a train to Rome.

Things to do in Florence

Historic Sites Museums

Side Trip

Duomo di Pisa
Find places to stay Oct 31 — Nov 3:
Highlights from your plan
Piazza del Duomo ©
Piazza del Duomo
Gallerie Degli Uffizi ©
Gallerie Degli Uffizi
Centro Storico ©
Centro Storico

3
nights
Rome, Italy

Rome ©
Aptly nicknamed the Eternal City, Rome is the birthplace of the Roman Empire, one of the world's greatest civilizations ever.
Eschew the tourist crowds and head to Palatine Hill and Galleria Borghese. Let the collections at Vatican Museums and Museo Nazionale Romano - Palazzo Massimo alle Terme capture your imagination. There's still lots to do: contemplate the long history of St. Peter's Basilica, pause for some serene contemplation at Basilica di Santa Maria degli Angeli e dei Martiri, stroll the grounds of Vatican Necropolis, and admire the striking features of Chiesa del Gesu.

To see more things to do, other places to visit, reviews, and tourist information, read Rome vacation website.

You can take a train from Florence to Rome in 2 hours. Other options are to drive; or fly. In November, daily temperatures in Rome can reach 63°F, while at night they dip to 47°F. Finish your sightseeing early on the 6th (Wed) so you can travel back home.

Things to do in Rome

Historic Sites Museums Nature

Side Trip

Vatican City
Find places to stay Nov 3 — 6:
Highlights from your plan
Palatine Hill ©
Palatine Hill
Colosseum ©
Colosseum
Pantheon ©
Pantheon

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